Research Abstracts
Abstracts are posted here as found, not as published. I claim no responsibility for the veracity of their findings or the impeccability of the study methods. When we cite studies, we gain credibility, deservedly or undeservedly. These findings may or may not enhance our actual practices. Occasionally, an abstract relating to an adjunct therapy will be included. Enjoy!
Moxibustion for the Correction of Nonvertex Presentation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Zhang QH, Yue JH, Liu M, Sun ZR, Sun Q, Han C, Wang D.
SourceDepartment of Acupuncture and Moxibustion, College of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
AbstractObjectives. This study aims to assess the effectiveness and safety of moxibustion for the correction of nonvertex presentation. Methods. Records without language restrictions were searched up to February 2013 for randomized controlled trials (RCTs) comparing moxibustion with other therapies in women with a singleton nonvertex presentation. Cochrane risk of bias criteria were used to assess the methodological quality of the trials. Results. Seven of 392 potentially relevant studies met the inclusion criteria. When moxibustion was compared with other interventions, a meta-analysis revealed a significant difference in favor of moxibustion on the correction of nonvertex presentation at delivery (risk ratio (RR) 1.29, 95% confidence interval (CI) 1.12 to 1.49, and I 2 = 0). The same findings applied to the cephalic presentation after cessation of treatment (RR 1.36, 95% CI 1.08 to 1.71, and I 2 = 80%). A subgroup analysis that excluded two trials with a high risk of bias also indicated favorable effects (RR 1.63, 95% CI 1.42 to 1.86, and I 2 = 0%). With respect to safety, moxibustion resulted in decreased use of oxytocin. Conclusion. Our systematic review and meta-analysis suggested that moxibustion may be an effective treatment for the correction of nonvertex presentation. Moreover, moxibustion might reduce the need for oxytocin.
PMID: 24159341 [PubMed - as supplied by publisher] PMCID: PMC3789399 Free PMC Article
SourceDepartment of Acupuncture and Moxibustion, College of Acupuncture and Moxibustion, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
AbstractObjectives. This study aims to assess the effectiveness and safety of moxibustion for the correction of nonvertex presentation. Methods. Records without language restrictions were searched up to February 2013 for randomized controlled trials (RCTs) comparing moxibustion with other therapies in women with a singleton nonvertex presentation. Cochrane risk of bias criteria were used to assess the methodological quality of the trials. Results. Seven of 392 potentially relevant studies met the inclusion criteria. When moxibustion was compared with other interventions, a meta-analysis revealed a significant difference in favor of moxibustion on the correction of nonvertex presentation at delivery (risk ratio (RR) 1.29, 95% confidence interval (CI) 1.12 to 1.49, and I 2 = 0). The same findings applied to the cephalic presentation after cessation of treatment (RR 1.36, 95% CI 1.08 to 1.71, and I 2 = 80%). A subgroup analysis that excluded two trials with a high risk of bias also indicated favorable effects (RR 1.63, 95% CI 1.42 to 1.86, and I 2 = 0%). With respect to safety, moxibustion resulted in decreased use of oxytocin. Conclusion. Our systematic review and meta-analysis suggested that moxibustion may be an effective treatment for the correction of nonvertex presentation. Moreover, moxibustion might reduce the need for oxytocin.
PMID: 24159341 [PubMed - as supplied by publisher] PMCID: PMC3789399 Free PMC Article
Indirect Moxibustion (CV4 and CV8) Ameliorates Chronic Fatigue: A Randomized, Double-Blind, Controlled Study.
J Altern Complement Med. 2012 Jul 3. [Epub ahead of print]
Indirect Moxibustion (CV4 and CV8) Ameliorates Chronic Fatigue: A Randomized, Double-Blind, Controlled Study. Kim HG, Yoo SR, Park HJ, Son CG.
SourceLiver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University , Daejeon, South Korea .
AbstractAbstract Objectives: The antifatigue effect of indirect moxibustion and its antioxidant properties were investigated. Subjects and design: A randomized, double-blind, controlled clinical trial was performed with 44 patients who had idiopathic chronic fatigue. The subjects were treated with a placebo or moxibustion (indirect moxibustion on CV4 and CV8 3 times per week for 4 weeks), and their fatigue severity was monitored using a self-rating numeric scale (NRS) and a visual analog scale (VAS). Serum level of reactive oxygen species and malondialdehyde (MDA), total antioxidant capacity, the activity of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase and total glutathione content, were determined before initial moxibustion therapy and after the 12th moxibustion treatment. Results: The moxibustion group had a significantly lower fatigue severity score compared to the control for both the NRS (p<0.05) and VAS scores (p<0.01). The level of serum MDA was significantly lower in the moxibustion group than in the placebo group (p<0.05), whereas glutathione reductase activity and total glutathione content increased significantly following moxibustion (p<0.05). Conclusions: The results provide clinical evidence for an antifatigue effect of indirect moxibustion at CV4 and CV8 and suggest that the effect is due to the antioxidant properties of moxibustion.
PMID: 22757691 [PubMed - as supplied by publisher]
Indirect Moxibustion (CV4 and CV8) Ameliorates Chronic Fatigue: A Randomized, Double-Blind, Controlled Study. Kim HG, Yoo SR, Park HJ, Son CG.
SourceLiver and Immunology Research Center, Daejeon Oriental Hospital of Oriental Medical College of Daejeon University , Daejeon, South Korea .
AbstractAbstract Objectives: The antifatigue effect of indirect moxibustion and its antioxidant properties were investigated. Subjects and design: A randomized, double-blind, controlled clinical trial was performed with 44 patients who had idiopathic chronic fatigue. The subjects were treated with a placebo or moxibustion (indirect moxibustion on CV4 and CV8 3 times per week for 4 weeks), and their fatigue severity was monitored using a self-rating numeric scale (NRS) and a visual analog scale (VAS). Serum level of reactive oxygen species and malondialdehyde (MDA), total antioxidant capacity, the activity of catalase, superoxide dismutase, glutathione peroxidase, and glutathione reductase and total glutathione content, were determined before initial moxibustion therapy and after the 12th moxibustion treatment. Results: The moxibustion group had a significantly lower fatigue severity score compared to the control for both the NRS (p<0.05) and VAS scores (p<0.01). The level of serum MDA was significantly lower in the moxibustion group than in the placebo group (p<0.05), whereas glutathione reductase activity and total glutathione content increased significantly following moxibustion (p<0.05). Conclusions: The results provide clinical evidence for an antifatigue effect of indirect moxibustion at CV4 and CV8 and suggest that the effect is due to the antioxidant properties of moxibustion.
PMID: 22757691 [PubMed - as supplied by publisher]
The effect of hand acupuncture therapy and hand moxibustion therapy on premenstrual syndrome among Korean women.
West J Nurs Res. 2009 Mar;31(2):171-86. Epub 2008 Sep 30.
The effect of hand acupuncture therapy and hand moxibustion therapy on premenstrual syndrome among Korean women.Shin KR, Ha JY, Park HJ, Heitkemper M.
SourceEwha Womans University.
AbstractPremenstrual syndrome (PMS) symptoms can reduce quality of life and impair daily functioning. This study examined the effects of Korean hand acupuncture therapy (HAT) and hand moxibustion therapy (HMT) on symptom severity in Korean women with PMS. This quasi-experimental pilot study based on the khi, yin, yang, and the five elements theory used a nonequivalent control group pretest-posttest design. Experimental groups received 10 sessions of either HAT or HMT treatment. Outcome measures included menstrual symptom severity as measured with the Menstrual Symptom Severity List and skin temperature change measured with Digital Infrared Thermographic Imaging. Both experimental groups had significantly reduced overall PMS symptom severity scores following therapy as compared to women in the control group. The HMT but not the HAT group showed improved flow of khi and balanced skin temperature in symmetric body areas. HAT and HMT may be effective strategies for women to reduce PMS symptoms.
PMID: 18829443 [PubMed - indexed for MEDLINE]
The effect of hand acupuncture therapy and hand moxibustion therapy on premenstrual syndrome among Korean women.Shin KR, Ha JY, Park HJ, Heitkemper M.
SourceEwha Womans University.
AbstractPremenstrual syndrome (PMS) symptoms can reduce quality of life and impair daily functioning. This study examined the effects of Korean hand acupuncture therapy (HAT) and hand moxibustion therapy (HMT) on symptom severity in Korean women with PMS. This quasi-experimental pilot study based on the khi, yin, yang, and the five elements theory used a nonequivalent control group pretest-posttest design. Experimental groups received 10 sessions of either HAT or HMT treatment. Outcome measures included menstrual symptom severity as measured with the Menstrual Symptom Severity List and skin temperature change measured with Digital Infrared Thermographic Imaging. Both experimental groups had significantly reduced overall PMS symptom severity scores following therapy as compared to women in the control group. The HMT but not the HAT group showed improved flow of khi and balanced skin temperature in symmetric body areas. HAT and HMT may be effective strategies for women to reduce PMS symptoms.
PMID: 18829443 [PubMed - indexed for MEDLINE]
[Effects of acupoint heat-sensitization moxibustion on the gastrin and motilin in chronic diarrhea patients of Pi-Shen deficiency syndrome].[Article in Chinese]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Apr;32(4):460-3.
[Effects of acupoint heat-sensitization moxibustion on the gastrin and motilin in chronic diarrhea patients of Pi-Shen deficiency syndrome].[Article in Chinese]
He L, Jiang GP, Liu H.
SourceThe Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006. [email protected]
Abstract OBJECTIVE:To observe the therapeutic efficacy of acupoint heat-sensitization moxibustion on chronic diarrhea patients as well as its effects on the levels of gastrointestinal neurotic mediators such as serum gastrin (GAS) and plasma motilin (MTL).
METHODS:Sixty chronic diarrhea patients of Pi-Shen deficiency syndrome were randomly assigned to Group A (30 cases, treated with acupoint heat-sensitization moxibustion, once daily) and Group B (30 cases, treated with Changtai Oral Liquid, 10 mL each time, three times daily). The therapeutic course was 4 weeks. Another 20 healthy volunteers were recruited as the health control group. The levels of serum GAS and plasma MTL were detected using radioimmunoassay before and after treatment. The cured rate, the markedly effective case, the effective case, the ineffective case, and the total effective rate were calculated by the end of the treatment.
RESULTS:Before treatment the serum GAS level was lower and the plasma MTL level higher in the two patient groups than in the health control group with statistical difference (P<0.05). There was no statistical difference in the symptom integral between the two patient groups and the health control group (P>0.05). After treatment the serum GAS level increased, the plasma MTL level and the symptom integral decreased in the two patient groups, showing statistical difference when compared with the same group before treatment (P<0.05, P<0.01). After treatment the symptom integral was lower in the treatment group than in the control group with statistical difference (P<0.05). There was no statistical difference in the GAS and MTL levels between the two patient groups (P>0.05). The total effective rate for clinical symptoms was significantly higher in Group A than in Group B with statistical difference (93.3% vs 73.3%, P<0.05).
CONCLUSIONS:The therapy of acupoint heat-sensitization moxibustion was effective for chronic diarrhea patients of Pi-Shen deficiency syn- drome. It could regulate the levels of serum GAS and plasma MTL and improve the patients' clinical symptoms.
PMID: 22803422 [PubMed - in process]
[Effects of acupoint heat-sensitization moxibustion on the gastrin and motilin in chronic diarrhea patients of Pi-Shen deficiency syndrome].[Article in Chinese]
He L, Jiang GP, Liu H.
SourceThe Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang 330006. [email protected]
Abstract OBJECTIVE:To observe the therapeutic efficacy of acupoint heat-sensitization moxibustion on chronic diarrhea patients as well as its effects on the levels of gastrointestinal neurotic mediators such as serum gastrin (GAS) and plasma motilin (MTL).
METHODS:Sixty chronic diarrhea patients of Pi-Shen deficiency syndrome were randomly assigned to Group A (30 cases, treated with acupoint heat-sensitization moxibustion, once daily) and Group B (30 cases, treated with Changtai Oral Liquid, 10 mL each time, three times daily). The therapeutic course was 4 weeks. Another 20 healthy volunteers were recruited as the health control group. The levels of serum GAS and plasma MTL were detected using radioimmunoassay before and after treatment. The cured rate, the markedly effective case, the effective case, the ineffective case, and the total effective rate were calculated by the end of the treatment.
RESULTS:Before treatment the serum GAS level was lower and the plasma MTL level higher in the two patient groups than in the health control group with statistical difference (P<0.05). There was no statistical difference in the symptom integral between the two patient groups and the health control group (P>0.05). After treatment the serum GAS level increased, the plasma MTL level and the symptom integral decreased in the two patient groups, showing statistical difference when compared with the same group before treatment (P<0.05, P<0.01). After treatment the symptom integral was lower in the treatment group than in the control group with statistical difference (P<0.05). There was no statistical difference in the GAS and MTL levels between the two patient groups (P>0.05). The total effective rate for clinical symptoms was significantly higher in Group A than in Group B with statistical difference (93.3% vs 73.3%, P<0.05).
CONCLUSIONS:The therapy of acupoint heat-sensitization moxibustion was effective for chronic diarrhea patients of Pi-Shen deficiency syn- drome. It could regulate the levels of serum GAS and plasma MTL and improve the patients' clinical symptoms.
PMID: 22803422 [PubMed - in process]
[Effect on therapeutic effect of inducing the formation of the post-moxibustion sore for bronchial asthma].[Article in Chinese]
Zhongguo Zhen Jiu. 2012 Apr;32(4):305-8.
[Effect on therapeutic effect of inducing the formation of the post-moxibustion sore for bronchial asthma].[Article in Chinese]
Sha JM, Deng XJ, Shao ZC.
SourceNursing Department, TCM Hospital of Rugao City, Rugao 226500, Jiangsu Province, China.
Abstract OBJECTIVE:To observe the impact of inducing the formation of the post-moxibustion sore on the efficacy of bronchial asthma treated with scarringmoxibustion.
METHODS:Three hundred and seventy-two cases diag nosed definitely as bronchial asthma at remission stage were randomly divided into a modified nursing group (248 cases) and a conventional nursing group (124 cases). The scarring moxibustion was applied at Dazhui (GV 14), Feishu (BL 13), Danzhong (CV 17) and Tiantu (CV 22) in either group. The direct moxibustion with moxa cone was adopted. In modified nursing group, 0.5% Iodine was used for the sterilization at moxa abscess. The herbal plaster was cut into an inverted triangle and compressed on the wound. After suppuration, the fester was not cleaned in each dressing change. Additionally, the patients were advised to have high-protein diets after moxibus tion till abscess dropped. In conventional nursing group, 0.5% Iodine was used for the sterilization at moxa abscess. The herbal plaster was cut into a round shape that could cover completely the moxa wound. After suppuration, in each dressing change, the wound was cleaned and sterilized. Additionally, the patients were advised to avoid any stimulating food after moxibustion till abscess dropped. The clinical efficacy, the change of C3 content in blood serum and the clinical symptom score were observed in two groups.
RESULTS:The total effective rate was 93.5% (232/248) in modified nursing group, which was better than 79.0% (98/124) in conventional nursing group (P < 0.01). C3 content increased apparently after treatment as compared with that before treatment in either group (both P < 0.01), but C3 level increased much more apparently in modified nursing group as compared with that in conventional nursing group (P < 0.01). The clinical symptom score reduced apparently after treatment in either group (both P < 0.01), but that reduced much more apparently in modified nursing group as compared with that in conventional nursing group (P < 0.01).
CONCLUSION:In the treatment of bronchial asthma with scarring moxibustion, to induce the formation of the post-moxibustion sore achieves the better clinical efficacy as compared with conventional nursing.
PMID: 22734375 [PubMed - indexed for MEDLINE]
[Effect on therapeutic effect of inducing the formation of the post-moxibustion sore for bronchial asthma].[Article in Chinese]
Sha JM, Deng XJ, Shao ZC.
SourceNursing Department, TCM Hospital of Rugao City, Rugao 226500, Jiangsu Province, China.
Abstract OBJECTIVE:To observe the impact of inducing the formation of the post-moxibustion sore on the efficacy of bronchial asthma treated with scarringmoxibustion.
METHODS:Three hundred and seventy-two cases diag nosed definitely as bronchial asthma at remission stage were randomly divided into a modified nursing group (248 cases) and a conventional nursing group (124 cases). The scarring moxibustion was applied at Dazhui (GV 14), Feishu (BL 13), Danzhong (CV 17) and Tiantu (CV 22) in either group. The direct moxibustion with moxa cone was adopted. In modified nursing group, 0.5% Iodine was used for the sterilization at moxa abscess. The herbal plaster was cut into an inverted triangle and compressed on the wound. After suppuration, the fester was not cleaned in each dressing change. Additionally, the patients were advised to have high-protein diets after moxibus tion till abscess dropped. In conventional nursing group, 0.5% Iodine was used for the sterilization at moxa abscess. The herbal plaster was cut into a round shape that could cover completely the moxa wound. After suppuration, in each dressing change, the wound was cleaned and sterilized. Additionally, the patients were advised to avoid any stimulating food after moxibustion till abscess dropped. The clinical efficacy, the change of C3 content in blood serum and the clinical symptom score were observed in two groups.
RESULTS:The total effective rate was 93.5% (232/248) in modified nursing group, which was better than 79.0% (98/124) in conventional nursing group (P < 0.01). C3 content increased apparently after treatment as compared with that before treatment in either group (both P < 0.01), but C3 level increased much more apparently in modified nursing group as compared with that in conventional nursing group (P < 0.01). The clinical symptom score reduced apparently after treatment in either group (both P < 0.01), but that reduced much more apparently in modified nursing group as compared with that in conventional nursing group (P < 0.01).
CONCLUSION:In the treatment of bronchial asthma with scarring moxibustion, to induce the formation of the post-moxibustion sore achieves the better clinical efficacy as compared with conventional nursing.
PMID: 22734375 [PubMed - indexed for MEDLINE]
THE ART OF MOXIBUSTION EDITOR'S NOTE: This type of treatment may not be possible in the United States due to limitations on scope of practice and liability exposure, however this information may still be of value in practice.
Regenerative effects of moxibustion on skeletal muscle in collagen-induced arthritic mice.
Regenerative effects of moxibustion on skeletal muscle in collagen-induced arthritic mice.Kim MJ, Namgung U, Hong KE.
SourceDepartment of Oriental Medicine, Daejeon University, Daejeon, Korea.
AbstractIn this study, we demonstrate that the direct application of moxibustion significantly enhances muscle regeneration in mice with collagen-induced arthritis (CIA). Twelve Dilute Brown Non-Agouti (DBA)/1 J male mice were randomly divided into the following groups: intact control (n=4), CIA (n=4), and CIA with moxibustion treatment (CIA+moxi, n=4). Mice in the CIA and CIA+moxi groups were immunized twice via intradermal injections of bovine type II collagen (C II) at 3-week intervals. After the second injection, moxibustion was applied to the mouse equivalent of the BL24 and ST36 acupoints with a moxa cone five times/day, every other day (except Sundays), for 3 weeks (a total of 9 treatments were administered). Phospho-Erk1/2, myostatin, TFG-B1, and IGF-1 were analyzed using ELISA. Protein levels in skeletal muscle tissues of the hind limb were analyzed by Western blotting and immunofluorescent staining. Treatment with direct moxibustion led to a marked improvement in CIA and atrophy of individual muscle fibers. Collagen protein signaling in the muscle of the CIA group was stronger than the control and CIA+moxi groups. Myostatin protein expression, as determined by Western blotting and immunofluorescent staining, were stronger in the CIA group compared with the control and CIA+moxi groups. Immunofluorescent staining confirmed that the CIA group had the strongest TGF-B1 protein signals among the three groups. However, in serum analysis the intact control group showed the strongest TGF-B1 protein signaling. RT-PCR analysis of the muscle tissues of the CIA+moxi group showed significant IGF-1 mRNA expression, and the most intense phospho-Erk1/2 protein signaling was detected in the muscle tissues of the CIA group via Western blotting and immunofluorescent staining. These results confirm that the direct administration of moxibustion at Shenshu (BL 23) and Zusanli (ST 36) influences muscle regeneration in the CIA mouse model. Our results suggest that the establishment of themoxibustion mechanism will encourage the clinical application of moxi.
Copyright © 2012. Published by Elsevier B.V.
PMID: 22682274 [PubMed - in process]
SourceDepartment of Oriental Medicine, Daejeon University, Daejeon, Korea.
AbstractIn this study, we demonstrate that the direct application of moxibustion significantly enhances muscle regeneration in mice with collagen-induced arthritis (CIA). Twelve Dilute Brown Non-Agouti (DBA)/1 J male mice were randomly divided into the following groups: intact control (n=4), CIA (n=4), and CIA with moxibustion treatment (CIA+moxi, n=4). Mice in the CIA and CIA+moxi groups were immunized twice via intradermal injections of bovine type II collagen (C II) at 3-week intervals. After the second injection, moxibustion was applied to the mouse equivalent of the BL24 and ST36 acupoints with a moxa cone five times/day, every other day (except Sundays), for 3 weeks (a total of 9 treatments were administered). Phospho-Erk1/2, myostatin, TFG-B1, and IGF-1 were analyzed using ELISA. Protein levels in skeletal muscle tissues of the hind limb were analyzed by Western blotting and immunofluorescent staining. Treatment with direct moxibustion led to a marked improvement in CIA and atrophy of individual muscle fibers. Collagen protein signaling in the muscle of the CIA group was stronger than the control and CIA+moxi groups. Myostatin protein expression, as determined by Western blotting and immunofluorescent staining, were stronger in the CIA group compared with the control and CIA+moxi groups. Immunofluorescent staining confirmed that the CIA group had the strongest TGF-B1 protein signals among the three groups. However, in serum analysis the intact control group showed the strongest TGF-B1 protein signaling. RT-PCR analysis of the muscle tissues of the CIA+moxi group showed significant IGF-1 mRNA expression, and the most intense phospho-Erk1/2 protein signaling was detected in the muscle tissues of the CIA group via Western blotting and immunofluorescent staining. These results confirm that the direct administration of moxibustion at Shenshu (BL 23) and Zusanli (ST 36) influences muscle regeneration in the CIA mouse model. Our results suggest that the establishment of themoxibustion mechanism will encourage the clinical application of moxi.
Copyright © 2012. Published by Elsevier B.V.
PMID: 22682274 [PubMed - in process]
FREE TEXT Is There Difference between the Effects of Two-Dose Stimulation for Knee Osteoarthritis in the Treatment of Heat-Sensitive Moxibustion?
Evid Based Complement Alternat Med. 2012;2012:696498. Epub 2012 Jun 7.
Is There Difference between the Effects of Two-Dose Stimulation for Knee Osteoarthritis in the Treatment of Heat-Sensitive Moxibustion?Chen R, Chen M, Xiong J, Chi Z, Zhou M, Su T, Sun J, Yi F, Zhang B.
SourceAcupuncture and Rehabilitation Department, The Affiliated Hospital, Jiangxi University of TCM, 445 Bayi Avenue, Nanchang 330006, China.
Abstract Considering that the dosage of manipulating Moxa plays an important role in obtaining good effects for heat-sensitive moxibustion, it would be valuable to know whether the use of fixed dosage is as effective as the use of an individual one. The paper carried out a rigorous multi-centre randomized controlled trial, and its result demonstrated that the effectiveness of individual eliminate-sensitive dosing regimen might more superior to the stable conventional dosing regimen in the treatment of KOA. According the record of individual moxibustion time, the dosage differed in the terms of patients' conditions and moxibustion sensation, which had been measured about 47.30 ± 6.20 minutes (28 ~ 65 minutes).
PMID: 22719788 [PubMed - in process] PMCID: PMC3375167 Free PMC Article
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Is There Difference between the Effects of Two-Dose Stimulation for Knee Osteoarthritis in the Treatment of Heat-Sensitive Moxibustion?Chen R, Chen M, Xiong J, Chi Z, Zhou M, Su T, Sun J, Yi F, Zhang B.
SourceAcupuncture and Rehabilitation Department, The Affiliated Hospital, Jiangxi University of TCM, 445 Bayi Avenue, Nanchang 330006, China.
Abstract Considering that the dosage of manipulating Moxa plays an important role in obtaining good effects for heat-sensitive moxibustion, it would be valuable to know whether the use of fixed dosage is as effective as the use of an individual one. The paper carried out a rigorous multi-centre randomized controlled trial, and its result demonstrated that the effectiveness of individual eliminate-sensitive dosing regimen might more superior to the stable conventional dosing regimen in the treatment of KOA. According the record of individual moxibustion time, the dosage differed in the terms of patients' conditions and moxibustion sensation, which had been measured about 47.30 ± 6.20 minutes (28 ~ 65 minutes).
PMID: 22719788 [PubMed - in process] PMCID: PMC3375167 Free PMC Article
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FREE TEXT The effects of scraping therapy on local temperature and blood perfusion volume in healthy subjects.
Evid Based Complement Alternat Med. 2012;2012:490292. Epub 2012 May 14.
The effects of scraping therapy on local temperature and blood perfusion volume in healthy subjects.Xu QY, Yang JS, Zhu B, Yang L, Wang YY, Gao XY.
SourceInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Abstract Objective. We aim to study the therapeutic effects of scraping by investigating the changes of temperature and local blood perfusion volume in healthy subjects after scraping stimulation, and to explore the mechanism of scraping stimulation from the points of microcirculation and energy metabolism. Methods. Twenty-three health subjects were included in this study. Local blood perfusion volume and body surface temperature was detected at 5 min before scraping stimulation, 0, 15, 30, 60 and 90 min after scraping using Laser Doppler imager and infrared thermograph. Results. Significant increase was noted in the blood perfusion volume in the scraping area within 90 minutes compared to the baseline level and non-scraping area (P < 0.001). Compared with non-scraping area, an increase of body temperature with an average of 1°C was observed after scraping stimulation (P < 0.01). Conclusion. Scraping can significantly improve the blood perfusion volume and increase the temperature in the scraping area, promoting the localblood circulation and energy metabolism.
PMID: 22666292 [PubMed - in process] PMCID: PMC3359830 Free PMC Article
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The effects of scraping therapy on local temperature and blood perfusion volume in healthy subjects.Xu QY, Yang JS, Zhu B, Yang L, Wang YY, Gao XY.
SourceInstitute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Abstract Objective. We aim to study the therapeutic effects of scraping by investigating the changes of temperature and local blood perfusion volume in healthy subjects after scraping stimulation, and to explore the mechanism of scraping stimulation from the points of microcirculation and energy metabolism. Methods. Twenty-three health subjects were included in this study. Local blood perfusion volume and body surface temperature was detected at 5 min before scraping stimulation, 0, 15, 30, 60 and 90 min after scraping using Laser Doppler imager and infrared thermograph. Results. Significant increase was noted in the blood perfusion volume in the scraping area within 90 minutes compared to the baseline level and non-scraping area (P < 0.001). Compared with non-scraping area, an increase of body temperature with an average of 1°C was observed after scraping stimulation (P < 0.01). Conclusion. Scraping can significantly improve the blood perfusion volume and increase the temperature in the scraping area, promoting the localblood circulation and energy metabolism.
PMID: 22666292 [PubMed - in process] PMCID: PMC3359830 Free PMC Article
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[Treatment of herpes zoster with cotton sheet moxibustion: multicentral randomized controlled trial].[Article in Chinese]
Zhongguo Zhen Jiu. 2012 May;32(5):417-21.
[Treatment of herpes zoster with cotton sheet moxibustion: multicentral randomized controlled trial].[Article in Chinese]
Yang JX, Xiang KW, Zhang YX.
SourceDepartment of Acupuncture and Moxibustion, Affiliated Hospital of Tongren Vocational Technical College, Tongren 554300, Guizhou Province, China. [email protected]
AbstractOBJECTIVE:To compare the therapeutic effects and safety of herpes zoster treated by the cotton sheet moxibustion combined with the plum-blossom-needle tapping therapy to western medicine.
METHODS:The multicentral random controlled method was adopted, 120 cases of herpes zoster were randomly divided into a comprehensive treatment group and a western medication group, 60 cases in each one. In the comprehensive treatment group, the tapping therapy of plum blossom needle was applied to the foci, corresponding Jiaji (EX-B 2), Quchi (LI 11), Waiguan (TE 5), Zusanli (ST 36), Taichong (LR 3), etc. Afterward, the cotton sheet moxibustion was given. In western medication group, Acyclovir ointment for external application, Valaciclovir Hydrochloride tablets and Vitamin B1 for oral administration were prescribed. In 7 days of treatment, the clinical symptom score, effect time, efficacy and safety were observed before and after treatment between two groups. The recurrence of disease was followed up for 1 month.
RESULTS:In the comprehensive treatment group, the cured rate and the total effective rate were 80.0% (48/60) and 98.3% (59/60) separately, which were significantly better than 45.0% (27/60) and 71.7% (43/60) in western medication group separately (P < 0.01, P < 0.05). After treatment, in either group, the scores of clinical symptoms such as pain rating index (PRI), Visual Analogue Scale (VAS), present pain intensity (PPI), skin lesion and sleeping score, etc. were all reduced significantly (P < 0.01, P < 0.05). The score reducing was much more obvious in the comprehensive treatment group (P < 0.01, P < 0.05). In the comprehensive treatment group, the time of pain stopping, the time of blister stopping, the time of scarring and the time of healing were all shorter tha tn those in western medication group (P < 0.01, P < 0.05). In the follow-up observation, 1 case (1.6%) was recurred in the comprehensive treatment group and 8 cases (13.3%) were in western medication group. In western medication group, 6 cases presented mild adverse reactions.
CONCLUSION:The cotton sheet moxibustion combined with the plum-blossom-needle tapping therapy is advantageous at good efficacy, quick effect and short-time treatment for herpes zoster, which is apparently superior to the treatment with Acyclovir ointment for external application, Valaciclovir Hydrochloride tablets and Vitamin B1 for oral administration. It is the safe and effective therapy.
PMID: 22650127 [PubMed - indexed for MEDLINE]
[Treatment of herpes zoster with cotton sheet moxibustion: multicentral randomized controlled trial].[Article in Chinese]
Yang JX, Xiang KW, Zhang YX.
SourceDepartment of Acupuncture and Moxibustion, Affiliated Hospital of Tongren Vocational Technical College, Tongren 554300, Guizhou Province, China. [email protected]
AbstractOBJECTIVE:To compare the therapeutic effects and safety of herpes zoster treated by the cotton sheet moxibustion combined with the plum-blossom-needle tapping therapy to western medicine.
METHODS:The multicentral random controlled method was adopted, 120 cases of herpes zoster were randomly divided into a comprehensive treatment group and a western medication group, 60 cases in each one. In the comprehensive treatment group, the tapping therapy of plum blossom needle was applied to the foci, corresponding Jiaji (EX-B 2), Quchi (LI 11), Waiguan (TE 5), Zusanli (ST 36), Taichong (LR 3), etc. Afterward, the cotton sheet moxibustion was given. In western medication group, Acyclovir ointment for external application, Valaciclovir Hydrochloride tablets and Vitamin B1 for oral administration were prescribed. In 7 days of treatment, the clinical symptom score, effect time, efficacy and safety were observed before and after treatment between two groups. The recurrence of disease was followed up for 1 month.
RESULTS:In the comprehensive treatment group, the cured rate and the total effective rate were 80.0% (48/60) and 98.3% (59/60) separately, which were significantly better than 45.0% (27/60) and 71.7% (43/60) in western medication group separately (P < 0.01, P < 0.05). After treatment, in either group, the scores of clinical symptoms such as pain rating index (PRI), Visual Analogue Scale (VAS), present pain intensity (PPI), skin lesion and sleeping score, etc. were all reduced significantly (P < 0.01, P < 0.05). The score reducing was much more obvious in the comprehensive treatment group (P < 0.01, P < 0.05). In the comprehensive treatment group, the time of pain stopping, the time of blister stopping, the time of scarring and the time of healing were all shorter tha tn those in western medication group (P < 0.01, P < 0.05). In the follow-up observation, 1 case (1.6%) was recurred in the comprehensive treatment group and 8 cases (13.3%) were in western medication group. In western medication group, 6 cases presented mild adverse reactions.
CONCLUSION:The cotton sheet moxibustion combined with the plum-blossom-needle tapping therapy is advantageous at good efficacy, quick effect and short-time treatment for herpes zoster, which is apparently superior to the treatment with Acyclovir ointment for external application, Valaciclovir Hydrochloride tablets and Vitamin B1 for oral administration. It is the safe and effective therapy.
PMID: 22650127 [PubMed - indexed for MEDLINE]
Economic evaluation of treating herpes zoster with various methods of acupuncture and moxibustion.
J Tradit Chin Med. 2012 Mar;32(1):125-8.
Economic evaluation of treating herpes zoster with various methods of acupuncture and moxibustion.Li XW, Yang YK, Xie XM, Bai LN, Zhang XS.
SourceDoctorate postgraduate of Acupuncture, Moxibustion and Massage College of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
AbstractOBJECTIVE:To analyze the cost effect of surrounding acupuncture plus electric acupuncture, cotton-sheet moxibustion, puncturing with red-hot needles, tapping plus cupping on herpes zoster.
METHODS:Five hundred patients with herpes zoster were randomly divided into group A (surrounding acupuncture plus electric acupuncture), group B (cotton-sheet moxibustion), group C (puncturing with red-hot needles), group D (tapping plus cupping), and group E (Western medicine). The treatment was carried out twice a day in group E and once a day in the other four groups. The curative effect was observed on the 10th day of treatment; the cost was calculated for the five therapies, and the cost-effect ratio (C/E) and increment ratio (delta C/delta E) were analyzed.
RESULTS:After the 10-day treatment, there was no statistical difference (P > 0.05) in the curative effect among the five groups. Pain being alleviated one day faster than in group E amounted to a saving of RMB 21.90 yuan in group A, a saving of RMB 21.87 yuan in group B, a saving of RMB 26.00 yuan in group C, and a saving of RMB 20.23 yuan in group D. Compared with group C, the values of delta C/delta E were RMB 1.55, 2.81, and 0.21 yuan in groups A, B, and D, respectively.
CONCLUSIONS:The curative effect in groups A, B, C, and D was similar to that in group E, but the C/E was better than in group E.
PMID: 22594116 [PubMed - indexed for MEDLINE]
Economic evaluation of treating herpes zoster with various methods of acupuncture and moxibustion.Li XW, Yang YK, Xie XM, Bai LN, Zhang XS.
SourceDoctorate postgraduate of Acupuncture, Moxibustion and Massage College of Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China.
AbstractOBJECTIVE:To analyze the cost effect of surrounding acupuncture plus electric acupuncture, cotton-sheet moxibustion, puncturing with red-hot needles, tapping plus cupping on herpes zoster.
METHODS:Five hundred patients with herpes zoster were randomly divided into group A (surrounding acupuncture plus electric acupuncture), group B (cotton-sheet moxibustion), group C (puncturing with red-hot needles), group D (tapping plus cupping), and group E (Western medicine). The treatment was carried out twice a day in group E and once a day in the other four groups. The curative effect was observed on the 10th day of treatment; the cost was calculated for the five therapies, and the cost-effect ratio (C/E) and increment ratio (delta C/delta E) were analyzed.
RESULTS:After the 10-day treatment, there was no statistical difference (P > 0.05) in the curative effect among the five groups. Pain being alleviated one day faster than in group E amounted to a saving of RMB 21.90 yuan in group A, a saving of RMB 21.87 yuan in group B, a saving of RMB 26.00 yuan in group C, and a saving of RMB 20.23 yuan in group D. Compared with group C, the values of delta C/delta E were RMB 1.55, 2.81, and 0.21 yuan in groups A, B, and D, respectively.
CONCLUSIONS:The curative effect in groups A, B, C, and D was similar to that in group E, but the C/E was better than in group E.
PMID: 22594116 [PubMed - indexed for MEDLINE]
Assessing the feasibility of using acupuncture and moxibustion to improve quality of life for cancer survivors with upper body lymphoedema.
Eur J Oncol Nurs. 2012 Jul;16(3):301-9. Epub 2011 Sep 13.
Assessing the feasibility of using acupuncture and moxibustion to improve quality of life for cancer survivors with upper body lymphoedema.de Valois BA, Young TE, Melsome E.
SourceSupportive Oncology Research Team, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN, United Kingdom. [email protected]
AbstractPURPOSE:Within a three-step mixed-methods study to investigate using acupuncture and moxibustion (acu/moxa) in the management of cancer treatment-related upper body lymphoedema, Step 2 obtained preliminary data about: 1) whether acu/moxa can improve quality of life, 2) the most troublesome symptoms, and 3) adverse effects.
METHODS AND SAMPLE:An exploratory single-arm observational clinical study included breast (BC) and head and neck cancer (HNC) survivors with mild-to-moderate uncomplicated lymphoedema for ≥3 months, ≥3 months post active-cancer treatment, no active cancer disease, undergoing routine lymphoedema maintenance. Participants received seven individualised treatments (S1), and six optional additional treatments (S2). MYMOP, SF-36 and PANAS were administered at baseline, during each series, and at follow-up 4 and 12 weeks after end-of-treatment. The primary outcome was change in MYMOP scores at the end of each series.
KEY RESULTS:Of 35 participants recruited, 30 completed S1 and S2, 3 completed S1, 2 were lost to the study. Mean MYMOP profile change scores for BC participants were 1.28 points improvement on a 7-point scale (sd = 0.93, p < 0.0001, n = 25) for S1; and 1.41 for S2 (sd = 0.94, p < 0.0001, n = 24). S1 HNC change scores were 2.29 points improvement (sd = 0.62, p < 0.0001, n = 7); and 0.94 for S2 (sd = 0.95, p = 0.06, n = 6). Changes in some SF-36 scores for BC participants were significant to 4 weeks after treatment. No serious adverse effects were reported.
CONCLUSION:This small study suggests acu/moxa is an acceptable adjunct to usual care for cancer survivors with lymphoedema. Further rigorous research is warranted to explore the effectiveness of acu/moxa in reducing the symptom burden.
Copyright © 2011 Elsevier Ltd. All rights reserved.
PMID: 21917515 [PubMed - in process]
Assessing the feasibility of using acupuncture and moxibustion to improve quality of life for cancer survivors with upper body lymphoedema.de Valois BA, Young TE, Melsome E.
SourceSupportive Oncology Research Team, Mount Vernon Cancer Centre, Rickmansworth Road, Northwood, Middlesex HA6 2RN, United Kingdom. [email protected]
AbstractPURPOSE:Within a three-step mixed-methods study to investigate using acupuncture and moxibustion (acu/moxa) in the management of cancer treatment-related upper body lymphoedema, Step 2 obtained preliminary data about: 1) whether acu/moxa can improve quality of life, 2) the most troublesome symptoms, and 3) adverse effects.
METHODS AND SAMPLE:An exploratory single-arm observational clinical study included breast (BC) and head and neck cancer (HNC) survivors with mild-to-moderate uncomplicated lymphoedema for ≥3 months, ≥3 months post active-cancer treatment, no active cancer disease, undergoing routine lymphoedema maintenance. Participants received seven individualised treatments (S1), and six optional additional treatments (S2). MYMOP, SF-36 and PANAS were administered at baseline, during each series, and at follow-up 4 and 12 weeks after end-of-treatment. The primary outcome was change in MYMOP scores at the end of each series.
KEY RESULTS:Of 35 participants recruited, 30 completed S1 and S2, 3 completed S1, 2 were lost to the study. Mean MYMOP profile change scores for BC participants were 1.28 points improvement on a 7-point scale (sd = 0.93, p < 0.0001, n = 25) for S1; and 1.41 for S2 (sd = 0.94, p < 0.0001, n = 24). S1 HNC change scores were 2.29 points improvement (sd = 0.62, p < 0.0001, n = 7); and 0.94 for S2 (sd = 0.95, p = 0.06, n = 6). Changes in some SF-36 scores for BC participants were significant to 4 weeks after treatment. No serious adverse effects were reported.
CONCLUSION:This small study suggests acu/moxa is an acceptable adjunct to usual care for cancer survivors with lymphoedema. Further rigorous research is warranted to explore the effectiveness of acu/moxa in reducing the symptom burden.
Copyright © 2011 Elsevier Ltd. All rights reserved.
PMID: 21917515 [PubMed - in process]
[Impacts of acupuncture and moxibustion on outcome indeices [sic] of depression patients' subjective reports].[Article in Chinese]
Zhongguo Zhen Jiu. 2012 May;32(5):385-9.
[Impacts of acupuncture and moxibustion on outcome indeices of depression patients' subjective reports].[Article in Chinese]
Fan L, Fu WB, Xu NG, Liu JH, Fan L, Ou AH.
SourceDepartment of Acupuncture and Moxibustion, Guangdong Provincial Hospital of TCM, Guangzhou 510120, China.
AbstractOBJECTIVE:To assess the clinical efficacy of acupuncture and moxibustion on depression in view of the outcome indicators of the patient subjective reports.
METHODS:One hundred and sixty-three cases of depression being in compliance with the inclusive standards were randomized into a soothing-liver and regulating-mind group, an acupoint-shallow-puncturing group and a non-acupoint-shallow-puncturing group. In the soothing-liver and regulating-mind group, the conventional acupuncture was applied to the four-gate points [Hegu (LI 4) and Taichong (LR 3)], Baihui (GV 20) and Yintang (EX-HN 3), the direct moxibustion with moxa cone was applied to the four-flower points [Geshu (BL 17), Danshu (BL 19)]. Finally, the intradermal needling was used at Xinshu (BL 15) and Ganshu (BL 18). In the acupoint-shallow-puncturing group, the acupoints selected were same as those in the soothing-liver and regulating-mind group. But the needle insertion was shallower and the time of moxibustion was shorter. In the non-acupoint-shallow-puncturing group, the spots that were 10 mm lateral to those acupoints in the soothing-liver and regulating-mind group were selected. The operation was same as that in the acupoint-shallow-puncturing group. The treatment was given twice a week in three groups. Totally, 12 weeks of treatment were required. The score of symptom checklist 90 (SCL-90), the self-report symptom inventory was observed before treatment, 1 month and 3 months after treatment separately so as to assess the corresponding short-term, mid-term and long-term efficacies of the program of acupuncture andmoxibustion for soothing the liver and regulating the mind.
RESULTS:In each time-point after treatment, for the scores of somatization, obsessive-compulsive symptom, interpersonal sensitivity, depression, anxiety, hostility, paranoid ideation, psychoticism and the other 8 dimensionalities, in comparison between the soothing-liver and regulating-mind group and the non-acupoint-shallow-puncturing group, the differences were significant statistically (all P < 0.05). For the scores of depression, anxiety and hostility, in comparison between the soothing-liver and regulating-mind group and the acupoint-shallow-puncturing group, the differences were significant statistically (all P < 0.05).
CONCLUSION:Acupuncture and moxibustion can improve the scores of SCL-90 scale for the patients with depression. The outcome indicators of the patient subjective reports can accurately assess the clinical efficacy.
PMID: 22650118 [PubMed - indexed for MEDLINE]
[Impacts of acupuncture and moxibustion on outcome indeices of depression patients' subjective reports].[Article in Chinese]
Fan L, Fu WB, Xu NG, Liu JH, Fan L, Ou AH.
SourceDepartment of Acupuncture and Moxibustion, Guangdong Provincial Hospital of TCM, Guangzhou 510120, China.
AbstractOBJECTIVE:To assess the clinical efficacy of acupuncture and moxibustion on depression in view of the outcome indicators of the patient subjective reports.
METHODS:One hundred and sixty-three cases of depression being in compliance with the inclusive standards were randomized into a soothing-liver and regulating-mind group, an acupoint-shallow-puncturing group and a non-acupoint-shallow-puncturing group. In the soothing-liver and regulating-mind group, the conventional acupuncture was applied to the four-gate points [Hegu (LI 4) and Taichong (LR 3)], Baihui (GV 20) and Yintang (EX-HN 3), the direct moxibustion with moxa cone was applied to the four-flower points [Geshu (BL 17), Danshu (BL 19)]. Finally, the intradermal needling was used at Xinshu (BL 15) and Ganshu (BL 18). In the acupoint-shallow-puncturing group, the acupoints selected were same as those in the soothing-liver and regulating-mind group. But the needle insertion was shallower and the time of moxibustion was shorter. In the non-acupoint-shallow-puncturing group, the spots that were 10 mm lateral to those acupoints in the soothing-liver and regulating-mind group were selected. The operation was same as that in the acupoint-shallow-puncturing group. The treatment was given twice a week in three groups. Totally, 12 weeks of treatment were required. The score of symptom checklist 90 (SCL-90), the self-report symptom inventory was observed before treatment, 1 month and 3 months after treatment separately so as to assess the corresponding short-term, mid-term and long-term efficacies of the program of acupuncture andmoxibustion for soothing the liver and regulating the mind.
RESULTS:In each time-point after treatment, for the scores of somatization, obsessive-compulsive symptom, interpersonal sensitivity, depression, anxiety, hostility, paranoid ideation, psychoticism and the other 8 dimensionalities, in comparison between the soothing-liver and regulating-mind group and the non-acupoint-shallow-puncturing group, the differences were significant statistically (all P < 0.05). For the scores of depression, anxiety and hostility, in comparison between the soothing-liver and regulating-mind group and the acupoint-shallow-puncturing group, the differences were significant statistically (all P < 0.05).
CONCLUSION:Acupuncture and moxibustion can improve the scores of SCL-90 scale for the patients with depression. The outcome indicators of the patient subjective reports can accurately assess the clinical efficacy.
PMID: 22650118 [PubMed - indexed for MEDLINE]
Effects of mild-warming moxibustion on Bcl-2 and PKC expressions of peripheral blood in elderly people.
J Tradit Chin Med. 2012 Mar;32(1):45-51.
Effects of mild-warming moxibustion on Bcl-2 and PKC expressions of peripheral blood in elderly people.Shi Y, Cui YH, Wu HG, Zhang W, Zhao C, Liu HR, Guo LQ, Wu BL, Yu AZ, Zhang YY.
SourceShanghai University of TCM, Shanghai 201203, China.
Abstract OBJECTIVE:To explore the anti-aging effects of mild-warming moxibustion on Bcl-2 and PKC expression in peripheral blood and general symptoms in elderly people.
METHODS:A total of 61 elderly people and 30 non-elderly people were enrolled. The total effective rate of mild-warming moxibustion was assessed by symptom scores, and Bcl-2 and PKC expression in peripheral blood was detected by flow cytometry.
RESULTS:The total effective rate in the mild-warming moxibustion group was significantly higher than in the blank control group (P < 0.01). Bcl-2 and PKC expression rates in peripheral blood in the blank control group were lower than in the normal control group (< 0.01), but higher after mild-warmingmoxibustion (P < 0.01).
CONCLUSION:The anti-aging effects of mild-warming moxibustion may be due to increased Bcl-2 and PKC expression in peripheral blood in aged people.
PMID: 22594101 [PubMed - indexed for MEDLINE]
Effects of mild-warming moxibustion on Bcl-2 and PKC expressions of peripheral blood in elderly people.Shi Y, Cui YH, Wu HG, Zhang W, Zhao C, Liu HR, Guo LQ, Wu BL, Yu AZ, Zhang YY.
SourceShanghai University of TCM, Shanghai 201203, China.
Abstract OBJECTIVE:To explore the anti-aging effects of mild-warming moxibustion on Bcl-2 and PKC expression in peripheral blood and general symptoms in elderly people.
METHODS:A total of 61 elderly people and 30 non-elderly people were enrolled. The total effective rate of mild-warming moxibustion was assessed by symptom scores, and Bcl-2 and PKC expression in peripheral blood was detected by flow cytometry.
RESULTS:The total effective rate in the mild-warming moxibustion group was significantly higher than in the blank control group (P < 0.01). Bcl-2 and PKC expression rates in peripheral blood in the blank control group were lower than in the normal control group (< 0.01), but higher after mild-warmingmoxibustion (P < 0.01).
CONCLUSION:The anti-aging effects of mild-warming moxibustion may be due to increased Bcl-2 and PKC expression in peripheral blood in aged people.
PMID: 22594101 [PubMed - indexed for MEDLINE]
Cephalic version by moxibustion for breech presentation.
Cochrane Database Syst Rev. 2012 May 16;5:CD003928.
Cephalic version by moxibustion for breech presentation.Coyle ME, Smith CA, Peat B.
SourceSchool of Nursing and Midwifery,Monash University,Churchill, Australia. [email protected].
AbstractBACKGROUND:Moxibustion (a type of Chinese medicine which involves burning a herb close to the skin) to the acupuncture point Bladder 67 (BL67) (Chinese name Zhiyin), located at the tip of the fifth toe, has been proposed as a way of correcting breech presentation.
OBJECTIVES:To examine the effectiveness and safety of moxibustion on changing the presentation of an unborn baby in the breech position, the need for external cephalic version (ECV), mode of birth, and perinatal morbidity and mortality for breech presentation.
SEARCH METHODS:We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (26 March 2012), MEDLINE (1966 to 1 August 2011), EMBASE (1980 to August 2011), CINAHL (1982 to 1 August 2011), MIDIRS (1982 to 1 August 2011) and AMED (1985 to 1 August 2011) and searched bibliographies of relevant papers.
SELECTION CRITERIA:The inclusion criteria were published and unpublished randomised controlled trials comparing moxibustion (either alone or in combination with acupuncture or postural techniques) with a control group (no moxibustion), or other methods (e.g. external cephalic version, acupuncture, postural techniques) in women with a singleton breech presentation.
DATA COLLECTION AND ANALYSIS:Two review authors independently assessed eligibility and trial quality and extracted data. The outcome measures were baby's presentation at birth, need for external cephalic version, mode of birth, perinatal morbidity and mortality, maternal complications and maternal satisfaction, and adverse events.
MAIN RESULTS:Six new trials have been added to this updated review. One trial has been moved to studies awaiting classification while further data are being requested. This updated review now includes a total of eight trials (involving 1346 women). Meta-analyses were undertaken (where possible) for the main and secondary outcomes. Moxibustion was not found to reduce the number of non-cephalic presentations at birth compared with no treatment (P = 0.45). Moxibustion resulted in decreased use of oxytocin before or during labour for women who had vaginal deliveries compared with no treatment (risk ratio (RR) 0.28, 95% confidence interval (CI) 0.13 to 0.60). Moxibustion was found to result in fewer non-cephalic presentations at birth compared with acupuncture (RR 0.25, 95% CI 0.09 to 0.72). When combined with acupuncture, moxibustion resulted in fewer non-cephalic presentations at birth (RR 0.73, 95% CI 0.57 to 0.94), and fewer births by caesarean section (RR 0.79, 95% CI 0.64 to 0.98) compared with no treatment. When combined with a postural technique, moxibustion was found to result in fewer non-cephalic presentations at birth compared with the postural technique alone (RR 0.26, 95% CI 0.12 to 0.56).
AUTHORS' CONCLUSIONS:This review found limited evidence to support the use of moxibustion for correcting breech presentation. There is some evidence to suggest that the use of moxibustion may reduce the need for oxytocin. When combined with acupuncture, moxibustion may result in fewer births by caesarean section; and when combined with postural management techniques may reduce the number of non-cephalic presentations at birth, however, there is a need for well-designed randomised controlled trials to evaluate moxibustion for breech presentation which report on clinically relevant outcomes as well as the safety of the intervention.
Update of
PMID: 22592693 [PubMed - indexed for MEDLINE]
Cephalic version by moxibustion for breech presentation.Coyle ME, Smith CA, Peat B.
SourceSchool of Nursing and Midwifery,Monash University,Churchill, Australia. [email protected].
AbstractBACKGROUND:Moxibustion (a type of Chinese medicine which involves burning a herb close to the skin) to the acupuncture point Bladder 67 (BL67) (Chinese name Zhiyin), located at the tip of the fifth toe, has been proposed as a way of correcting breech presentation.
OBJECTIVES:To examine the effectiveness and safety of moxibustion on changing the presentation of an unborn baby in the breech position, the need for external cephalic version (ECV), mode of birth, and perinatal morbidity and mortality for breech presentation.
SEARCH METHODS:We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (26 March 2012), MEDLINE (1966 to 1 August 2011), EMBASE (1980 to August 2011), CINAHL (1982 to 1 August 2011), MIDIRS (1982 to 1 August 2011) and AMED (1985 to 1 August 2011) and searched bibliographies of relevant papers.
SELECTION CRITERIA:The inclusion criteria were published and unpublished randomised controlled trials comparing moxibustion (either alone or in combination with acupuncture or postural techniques) with a control group (no moxibustion), or other methods (e.g. external cephalic version, acupuncture, postural techniques) in women with a singleton breech presentation.
DATA COLLECTION AND ANALYSIS:Two review authors independently assessed eligibility and trial quality and extracted data. The outcome measures were baby's presentation at birth, need for external cephalic version, mode of birth, perinatal morbidity and mortality, maternal complications and maternal satisfaction, and adverse events.
MAIN RESULTS:Six new trials have been added to this updated review. One trial has been moved to studies awaiting classification while further data are being requested. This updated review now includes a total of eight trials (involving 1346 women). Meta-analyses were undertaken (where possible) for the main and secondary outcomes. Moxibustion was not found to reduce the number of non-cephalic presentations at birth compared with no treatment (P = 0.45). Moxibustion resulted in decreased use of oxytocin before or during labour for women who had vaginal deliveries compared with no treatment (risk ratio (RR) 0.28, 95% confidence interval (CI) 0.13 to 0.60). Moxibustion was found to result in fewer non-cephalic presentations at birth compared with acupuncture (RR 0.25, 95% CI 0.09 to 0.72). When combined with acupuncture, moxibustion resulted in fewer non-cephalic presentations at birth (RR 0.73, 95% CI 0.57 to 0.94), and fewer births by caesarean section (RR 0.79, 95% CI 0.64 to 0.98) compared with no treatment. When combined with a postural technique, moxibustion was found to result in fewer non-cephalic presentations at birth compared with the postural technique alone (RR 0.26, 95% CI 0.12 to 0.56).
AUTHORS' CONCLUSIONS:This review found limited evidence to support the use of moxibustion for correcting breech presentation. There is some evidence to suggest that the use of moxibustion may reduce the need for oxytocin. When combined with acupuncture, moxibustion may result in fewer births by caesarean section; and when combined with postural management techniques may reduce the number of non-cephalic presentations at birth, however, there is a need for well-designed randomised controlled trials to evaluate moxibustion for breech presentation which report on clinically relevant outcomes as well as the safety of the intervention.
Update of
PMID: 22592693 [PubMed - indexed for MEDLINE]
[Analysis on therapeutic effect of variable-frequency electroacupuncture combined with herbal-moxa moxibustion for post-zoster neuralgia].[Article in Chinese]
Zhen Ci Yan Jiu. 2012 Feb;37(1):64-6.
[Analysis on therapeutic effect of variable-frequency electroacupuncture combined with herbal-moxa moxibustion for post-zoster neuralgia].[Article in Chinese]
Wang CY, Fang JQ.
SourceThe Third Affiliated Hospital of Zhejiang University of Chinese Medicine, Hang-zhou 310005, China. [email protected]
AbstractOBJECTIVE:To observe the clinical therapeutic effect of variable-frequency electroacupuncture (EA) combined with herbal-moxa moxibustion for regional neuralgia in herpes zoster (HZ) patients.
METHODS:A total of 37 cases of HZ outpatients were randomized into treatment group (18 cases) and medication group (19 cases). For patients of the treatment group, EA (100 Hz for the 1st 10 min, then 2 Hz for 30 min) plus herbal-moxa roll (15 cm in length, containing components of corydalis tuber, astragali radix, myrrh, etc.) moxibustion (till local skin flushing, and the patient's warm feeling penetrated from the skin surface to the deeper subcutaneous tissues, ignited nine times repeatedly) was applied to Jiaji (EX-B 2) and Ashi-point, once daily for 7 days. Patients of the medication group were ordered to take Brufen (0.3 g, b. i. d.), vitamin B 1 (10 mg, t. i. d.) and vitamin E (100 mg, b. i. d). The visual analog scale (VAS) was used to assess the HZ patients' pain reaction before and after the therapy.
RESULTS:After one course of treatment, of the 19 and 18 HZ patients in the medication and treatment groups, 1 (5.26%) and 5 (27.77%) were cured, 13 (68.42%) and 12 (66.67%) ameliorated, 5 (26.32%) and 1 (5.56%) invalid, with the total effective rates being 73.68% and 94.44% respectively. The therapeutic effect of the treatment group was significantly superior to that of the medication group (P < 0.05). VAS scores of both groups were decreased considerably following the treatment (P < 0.05), but showed no significant difference between the two groups (P > 0.05).
CONCLUSION:Variable-frequency EA plus herbal-moxa roll moxibustion is effective in relieving neuralgia of HZ patients.
PMID: 22574572 [PubMed - indexed for MEDLINE]
[Analysis on therapeutic effect of variable-frequency electroacupuncture combined with herbal-moxa moxibustion for post-zoster neuralgia].[Article in Chinese]
Wang CY, Fang JQ.
SourceThe Third Affiliated Hospital of Zhejiang University of Chinese Medicine, Hang-zhou 310005, China. [email protected]
AbstractOBJECTIVE:To observe the clinical therapeutic effect of variable-frequency electroacupuncture (EA) combined with herbal-moxa moxibustion for regional neuralgia in herpes zoster (HZ) patients.
METHODS:A total of 37 cases of HZ outpatients were randomized into treatment group (18 cases) and medication group (19 cases). For patients of the treatment group, EA (100 Hz for the 1st 10 min, then 2 Hz for 30 min) plus herbal-moxa roll (15 cm in length, containing components of corydalis tuber, astragali radix, myrrh, etc.) moxibustion (till local skin flushing, and the patient's warm feeling penetrated from the skin surface to the deeper subcutaneous tissues, ignited nine times repeatedly) was applied to Jiaji (EX-B 2) and Ashi-point, once daily for 7 days. Patients of the medication group were ordered to take Brufen (0.3 g, b. i. d.), vitamin B 1 (10 mg, t. i. d.) and vitamin E (100 mg, b. i. d). The visual analog scale (VAS) was used to assess the HZ patients' pain reaction before and after the therapy.
RESULTS:After one course of treatment, of the 19 and 18 HZ patients in the medication and treatment groups, 1 (5.26%) and 5 (27.77%) were cured, 13 (68.42%) and 12 (66.67%) ameliorated, 5 (26.32%) and 1 (5.56%) invalid, with the total effective rates being 73.68% and 94.44% respectively. The therapeutic effect of the treatment group was significantly superior to that of the medication group (P < 0.05). VAS scores of both groups were decreased considerably following the treatment (P < 0.05), but showed no significant difference between the two groups (P > 0.05).
CONCLUSION:Variable-frequency EA plus herbal-moxa roll moxibustion is effective in relieving neuralgia of HZ patients.
PMID: 22574572 [PubMed - indexed for MEDLINE]
Moxibustion Inhibits Apoptosis and Tumor Necrosis Factor-Alpha/Tumor Necrosis Factor Receptor 1 in the Colonic Epithelium of Crohn's Disease Model Rats.
Dig Dis Sci. 2012 Apr 25. [Epub ahead of print]
Moxibustion Inhibits Apoptosis and Tumor Necrosis Factor-Alpha/Tumor Necrosis Factor Receptor 1 in the Colonic Epithelium of Crohn's Disease Model Rats.Bao CH, Wu LY, Wu HG, Shi Y, Liu HR, Zhang R, Yu LQ, Wang JH.
SourceYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
AbstractBACKGROUND:Previous studies have shown that moxibustion on Tianshu (ST25) and Qihai (CV6) is effective for treating Crohn's disease. However, the mechanism of moxibustion has not been clearly elucidated.
AIM:The purpose of this study was to investigate the effect of moxibustion on the inhibition of colonic epithelial cell apoptosis and on tumor necrosis factor alpha (TNF-alpha) and tumor necrosis factor receptor TNF receptor-1 (TNFR1) and TNFR2 and to determine the mechanism of its protective effect using Crohn's disease (CD) model rats.
METHODS AND RESULTS:The experimental CD rat models were established by the administration of trinitrobenzene sulfonic acid. In the herbs-partitioned moxibustion (HPM) and mild-warm moxibustion (MWM) groups, moxibustion was administered to Tianshu (ST25) and Qihai (CV6) acupoints once daily for 14 days. In the salicylazosulfapyridine (SASP) group, SASP was administered twice daily for 14 days. A normal control (NC) group and a model control (MC) group were also studied. The levels of TNF-alpha and its mRNA, TNFR1 as well as the rate of colonic epithelial cell apoptosis were significantly decreased in the HPM, MWM and SASP groups compared with the MC group. The HPM and MWM groups had lower mRNA expression and lower protein levels of TNF-alpha compared to the SASP group. The HPM and MWM groups exhibited less apoptosis than the SASP group.
CONCLUSIONS:Moxibustion may inhibit colonic epithelial cell apoptosis by reducing the high expression of TNF-alpha and TNFR1 to protect the defective colonic epithelial barrier in CD model rats.
PMID: 22531889 [PubMed - as supplied by publisher]
Moxibustion Inhibits Apoptosis and Tumor Necrosis Factor-Alpha/Tumor Necrosis Factor Receptor 1 in the Colonic Epithelium of Crohn's Disease Model Rats.Bao CH, Wu LY, Wu HG, Shi Y, Liu HR, Zhang R, Yu LQ, Wang JH.
SourceYueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China.
AbstractBACKGROUND:Previous studies have shown that moxibustion on Tianshu (ST25) and Qihai (CV6) is effective for treating Crohn's disease. However, the mechanism of moxibustion has not been clearly elucidated.
AIM:The purpose of this study was to investigate the effect of moxibustion on the inhibition of colonic epithelial cell apoptosis and on tumor necrosis factor alpha (TNF-alpha) and tumor necrosis factor receptor TNF receptor-1 (TNFR1) and TNFR2 and to determine the mechanism of its protective effect using Crohn's disease (CD) model rats.
METHODS AND RESULTS:The experimental CD rat models were established by the administration of trinitrobenzene sulfonic acid. In the herbs-partitioned moxibustion (HPM) and mild-warm moxibustion (MWM) groups, moxibustion was administered to Tianshu (ST25) and Qihai (CV6) acupoints once daily for 14 days. In the salicylazosulfapyridine (SASP) group, SASP was administered twice daily for 14 days. A normal control (NC) group and a model control (MC) group were also studied. The levels of TNF-alpha and its mRNA, TNFR1 as well as the rate of colonic epithelial cell apoptosis were significantly decreased in the HPM, MWM and SASP groups compared with the MC group. The HPM and MWM groups had lower mRNA expression and lower protein levels of TNF-alpha compared to the SASP group. The HPM and MWM groups exhibited less apoptosis than the SASP group.
CONCLUSIONS:Moxibustion may inhibit colonic epithelial cell apoptosis by reducing the high expression of TNF-alpha and TNFR1 to protect the defective colonic epithelial barrier in CD model rats.
PMID: 22531889 [PubMed - as supplied by publisher]
[Effects of modxibustion [sic] on the expressions of hippocampal VEGF, flt-1, bFGF, and bFGF-r in vascular dementia rats].[Article in Chinese]
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Jan;32(1):97-101.
[Effects of modxibustion on the expressions of hippocampal VEGF, flt-1, bFGF, and bFGF-r in vascular dementia rats].[Article in Chinese]
Wang P, Tang JY, Yang J.
SourceAnhui College of Traditional Chinese Medicine, Hefei. [email protected]
AbstractOBJECTIVE:To observe the expression levels of hippocampal vascular endothelial growth factor (VEGF), fms-like tyrosine kinase-1 (flt-1), basic fibroblast growth factor (bFGF), and basic fibroblast growth factor receptor (bFGF-r) in vascular dementia (VD) rats, thus studying the angiogenesis mechanism of moxibustion in VD.
METHODS:Sixty male elderly Wistar rats were selected. The VD rat model was prepared by bilateral carotid artery occlusion and reperfusion of sodium nitroprusside injection. The model rats were divided into 3 groups by the random digit table, i. e., the moxibustion group, the Western medicine group, and the model group. A sham-operation control group was also set up. In the moxibustion group rats was acupunctured at Baihui (GV20), Shenting (GV14), and Dazhui (GV24). Aniracetam was given to rats in the Western medicine group by gastrogavage for 2 therapeutic courses, 15 days as one course. The learning and memory results were observed by the neuroethological score in combination of step-down avoidance test before treatment and by the end of the 2nd course respectively. The expression levels of hippocampal VEGF, flt-1, bFGF, and bFGF-r of all rats were detected using immunohistochemical assay.
RESULTS:After 2 courses of treatment, statistical difference existed in the latent period, the error times, and the neuroethological score in themoxibustion group and the Western medicine group when compared with the model group (P < 0.01, P < 0.05). Statistical difference existed in the latent period and the neuroethological score between the moxibustion group and the Western medicine group (P < 0.05), which indicated thatmoxibustion and Western medicine showed significant effects in improving the latent period, decreasing the error times and the neuroethological score. Better results were obtained in the moxibustion group than in the Western medicine group (P < 0.01, P < 0.05). Statistical difference of the average grey level (AGL) of hippocampal VEGF, flt-1, and bFGF existed in the moxibustion group and the Western medicine group when compared with the model group. Statistical difference of the bFGF-r expression existed only between the moxibustion group and the model group. Statistical difference of the VEGF and flt-1 expressions existed between the moxibustion group and the Western medicine group (P < 0.05).
CONCLUSIONS:Moxibustion showed confirmative effects in improving the behavioral score and memory performance in VD rats. Its mechanisms might lie in that moxibustion regulated and controlled the expression levels of hippocampal VEGF, flt-1, bFGF, and bFGF-r in VD rats. Particularly it up-regulated the expression levels of key factors VEGF and flt-1, promoted the angiogenesis in the vital parts, and ultimately stimulated the repairing mechanisms of cerebral nerve injury.
PMID: 22500404 [PubMed - in process]
[Effects of modxibustion on the expressions of hippocampal VEGF, flt-1, bFGF, and bFGF-r in vascular dementia rats].[Article in Chinese]
Wang P, Tang JY, Yang J.
SourceAnhui College of Traditional Chinese Medicine, Hefei. [email protected]
AbstractOBJECTIVE:To observe the expression levels of hippocampal vascular endothelial growth factor (VEGF), fms-like tyrosine kinase-1 (flt-1), basic fibroblast growth factor (bFGF), and basic fibroblast growth factor receptor (bFGF-r) in vascular dementia (VD) rats, thus studying the angiogenesis mechanism of moxibustion in VD.
METHODS:Sixty male elderly Wistar rats were selected. The VD rat model was prepared by bilateral carotid artery occlusion and reperfusion of sodium nitroprusside injection. The model rats were divided into 3 groups by the random digit table, i. e., the moxibustion group, the Western medicine group, and the model group. A sham-operation control group was also set up. In the moxibustion group rats was acupunctured at Baihui (GV20), Shenting (GV14), and Dazhui (GV24). Aniracetam was given to rats in the Western medicine group by gastrogavage for 2 therapeutic courses, 15 days as one course. The learning and memory results were observed by the neuroethological score in combination of step-down avoidance test before treatment and by the end of the 2nd course respectively. The expression levels of hippocampal VEGF, flt-1, bFGF, and bFGF-r of all rats were detected using immunohistochemical assay.
RESULTS:After 2 courses of treatment, statistical difference existed in the latent period, the error times, and the neuroethological score in themoxibustion group and the Western medicine group when compared with the model group (P < 0.01, P < 0.05). Statistical difference existed in the latent period and the neuroethological score between the moxibustion group and the Western medicine group (P < 0.05), which indicated thatmoxibustion and Western medicine showed significant effects in improving the latent period, decreasing the error times and the neuroethological score. Better results were obtained in the moxibustion group than in the Western medicine group (P < 0.01, P < 0.05). Statistical difference of the average grey level (AGL) of hippocampal VEGF, flt-1, and bFGF existed in the moxibustion group and the Western medicine group when compared with the model group. Statistical difference of the bFGF-r expression existed only between the moxibustion group and the model group. Statistical difference of the VEGF and flt-1 expressions existed between the moxibustion group and the Western medicine group (P < 0.05).
CONCLUSIONS:Moxibustion showed confirmative effects in improving the behavioral score and memory performance in VD rats. Its mechanisms might lie in that moxibustion regulated and controlled the expression levels of hippocampal VEGF, flt-1, bFGF, and bFGF-r in VD rats. Particularly it up-regulated the expression levels of key factors VEGF and flt-1, promoted the angiogenesis in the vital parts, and ultimately stimulated the repairing mechanisms of cerebral nerve injury.
PMID: 22500404 [PubMed - in process]
[Antipyretic effect of moxibustion at different temperatures and its relationship with the activity of temperature sensitive neurons in thermotaxic center].[Article in Chinese]
Zhongguo Zhen Jiu. 2012 Feb;32(2):149-54.
[Antipyretic effect of moxibustion at different temperatures and its relationship with the activity of temperature sensitive neurons in thermotaxic center].[Article in Chinese]
Dong XM, Dong QS, Zhang XQ, Zhu L.
SourceInstitute of Acupuncture-Moxibustion and Meridians, Sichuan Academy of Chinese Medical Sciences, Chengdu 610031, China.
AbstractOBJECTIVE:To discover the central mechanisms of antipyretic effect of moxibustion and its relationship with the acupoint sensor so as to provide the scientific evidence for "the treatment of heat syndrome with moxibustion".
METHODS:Eighteen New Zealand Rabbits were randomly assigned into three groups, named group A (modeling with intravenous injection of Endotoxin), group B (moxibustion at 40 degrees C after Endotoxin injection) and group C (moxibustion at 48 degrees C after Endotoxin injection), 6 rabbits in each one. The experiment was undergoing in the condition of muscular relaxation and artificial respiration for the animals. The spotlightmoxibustion at constant temperature was applied to "Zhiyang" (GV 9). The discharge of heat sensitive neurons (HSNs) at the preoptic region and anterior hypothalamus (POAH) was taken as the index. The impacts of the treatment on HSNs were observed in each group.
RESULTS AND CONCLUSION:Moxibustion had significant antagonism to the pyrogen on its inhibition to the activity of HSNs in the thermotaxic center. As a result, the antipyretic effect was obtained. It is concluded that the effective result of moxibustion is achieved by stimulating polymodal receptors of acupoints.
PMID: 22493923 [PubMed - indexed for MEDLINE]
[Antipyretic effect of moxibustion at different temperatures and its relationship with the activity of temperature sensitive neurons in thermotaxic center].[Article in Chinese]
Dong XM, Dong QS, Zhang XQ, Zhu L.
SourceInstitute of Acupuncture-Moxibustion and Meridians, Sichuan Academy of Chinese Medical Sciences, Chengdu 610031, China.
AbstractOBJECTIVE:To discover the central mechanisms of antipyretic effect of moxibustion and its relationship with the acupoint sensor so as to provide the scientific evidence for "the treatment of heat syndrome with moxibustion".
METHODS:Eighteen New Zealand Rabbits were randomly assigned into three groups, named group A (modeling with intravenous injection of Endotoxin), group B (moxibustion at 40 degrees C after Endotoxin injection) and group C (moxibustion at 48 degrees C after Endotoxin injection), 6 rabbits in each one. The experiment was undergoing in the condition of muscular relaxation and artificial respiration for the animals. The spotlightmoxibustion at constant temperature was applied to "Zhiyang" (GV 9). The discharge of heat sensitive neurons (HSNs) at the preoptic region and anterior hypothalamus (POAH) was taken as the index. The impacts of the treatment on HSNs were observed in each group.
RESULTS AND CONCLUSION:Moxibustion had significant antagonism to the pyrogen on its inhibition to the activity of HSNs in the thermotaxic center. As a result, the antipyretic effect was obtained. It is concluded that the effective result of moxibustion is achieved by stimulating polymodal receptors of acupoints.
PMID: 22493923 [PubMed - indexed for MEDLINE]
[Effect of aconite cake-separated moxibustion at Guanyuan (CV 4) and Mingmen (GV 4) on thyroid function in patients of Hashimoto's thyroiditis].[Article in Chinese]
Zhongguo Zhen Jiu. 2012 Feb;32(2):123-6.
[Effect of aconite cake-separated moxibustion at Guanyuan (CV 4) and Mingmen (GV 4) on thyroid function in patients of Hashimoto's thyroiditis].[Article in Chinese]
Xia Y, Xia MZ, Li Y, Liu SM, Ju ZY, He JS.
SourceCollege of Acupuncture-Moxibustion and Massage, Shanghai University of TCM, Shanghai 201203, China.
AbstractOBJECTIVE:To explore the effects on thyroid function in patients of Hashimoto's thyroiditis treated with aconite cake-separated moxibustion and option the better therapeutic program.
METHODS:Eighty-five cases were randomly divided into a moxibustion group (42 cases) and a western medication group (43 cases). Themoxibustion group was treated by aconite cake-separated moxibustion therapy with acupoints of two groups [(1) Danzhong (CV 17), Zhongwan (CV 12), Guanyuan (CV 4); (2) Dazhui (GV 14), Shenshu (BL 23), Mingmen (GV 4)] alternatively and oral administration of 25 microg Euthyrox everyday. The western medication group was oral administration of 25 microg Euthyrox everyday. Indices of thyroid function before and after treatment and clinical effect were compared between two groups.
RESULTS:The clinical total effective rate and effective rate of thyroid function were 25.0% (10/40), 87.5% (35/40) in moxibustion group respectively, 7.53% (3/40) and 57.5% (23/40) in western medication group, with significant differences between two groups (both P < 0.05). Content of serum free thyroxine index (FT4) increased significantly in the moxibustion group after treatment (P < 0.01); content of serum supersensitive thyrotropin (S-TSH) in the moxibustion group was lower than that of western medication group, and contents of serum FT4 and free triiodothyronine (FT3) were higher than those of western medication group, but with no significant differences (all P > 0.05).
CONCLUSION:Aconite cake-separated moxibustion at Guanyuan (CV 4) and Mingmen (GV 4) combined with oral administration of Euthyrox can improve clinical symptoms and thyroid function in patients of Hashimoto's thyroiditis, which is better than simple oral administration of Euthyrox.
PMID: 22493914 [PubMed - indexed for MEDLINE]
[Effect of aconite cake-separated moxibustion at Guanyuan (CV 4) and Mingmen (GV 4) on thyroid function in patients of Hashimoto's thyroiditis].[Article in Chinese]
Xia Y, Xia MZ, Li Y, Liu SM, Ju ZY, He JS.
SourceCollege of Acupuncture-Moxibustion and Massage, Shanghai University of TCM, Shanghai 201203, China.
AbstractOBJECTIVE:To explore the effects on thyroid function in patients of Hashimoto's thyroiditis treated with aconite cake-separated moxibustion and option the better therapeutic program.
METHODS:Eighty-five cases were randomly divided into a moxibustion group (42 cases) and a western medication group (43 cases). Themoxibustion group was treated by aconite cake-separated moxibustion therapy with acupoints of two groups [(1) Danzhong (CV 17), Zhongwan (CV 12), Guanyuan (CV 4); (2) Dazhui (GV 14), Shenshu (BL 23), Mingmen (GV 4)] alternatively and oral administration of 25 microg Euthyrox everyday. The western medication group was oral administration of 25 microg Euthyrox everyday. Indices of thyroid function before and after treatment and clinical effect were compared between two groups.
RESULTS:The clinical total effective rate and effective rate of thyroid function were 25.0% (10/40), 87.5% (35/40) in moxibustion group respectively, 7.53% (3/40) and 57.5% (23/40) in western medication group, with significant differences between two groups (both P < 0.05). Content of serum free thyroxine index (FT4) increased significantly in the moxibustion group after treatment (P < 0.01); content of serum supersensitive thyrotropin (S-TSH) in the moxibustion group was lower than that of western medication group, and contents of serum FT4 and free triiodothyronine (FT3) were higher than those of western medication group, but with no significant differences (all P > 0.05).
CONCLUSION:Aconite cake-separated moxibustion at Guanyuan (CV 4) and Mingmen (GV 4) combined with oral administration of Euthyrox can improve clinical symptoms and thyroid function in patients of Hashimoto's thyroiditis, which is better than simple oral administration of Euthyrox.
PMID: 22493914 [PubMed - indexed for MEDLINE]
The effect of herb-partition moxibustion on Toll-like receptor 4 in rabbit aorta during atherosclerosis.
J Acupunct Meridian Stud. 2012 Apr;5(2):72-9. Epub 2012 Feb 10.
The effect of herb-partition moxibustion on Toll-like receptor 4 in rabbit aorta during atherosclerosis.Yue ZH, He XQ, Chang XR, Yuan JL, Yu BS, Liu M, Fu L, Zhang L, Shang LC.
SourceCollege of Acu-Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha, Hunan, China.
AbstractOBJECTIVE:To explore the mechanism of Toll-like receptor (TLR4) inhibition in the delay of formation of atherosclerosis by herb-partitionmoxibustion.
METHOD:Seventy-five rabbits were randomly assigned to one of five groups: blank, atherosclerosis (AS) model, direct moxibustion, herb-partitionmoxibustion, and drug treatment. With the exception of the blank group, all rabbits were given a high-fat diet in addition to immunologic injury to create the AS model. The experiments were carried out for 16 weeks, at which time the aorta was removed from each rabbit. Immunohistochemical methods were used to detect the gray level of the aortic TLR4 to observe the immunologic competence of its antigens. Fluorescent quantitative polymerase chain reaction was used to detect the expression of TLR4 messenger RNA (mRNA) in the aorta.
RESULTS:The gray-scale value of TLR4 and the TLR4 mRNA expression significantly decreased (p<0.05) in the direct moxibustion, herb-partitionmoxibustion, and drug treatment groups. Furthermore, the effects of the herb-partition moxibustion and drug treatment were superior to those of the direct moxibustion.
CONCLUSION:Herb-partition moxibustion inhibits aortic TLR4 activity and mRNA expression, showing that herb-partition moxibustion delays the formation of atherosclerosis through the inhibition of TLR4 expression.
Copyright © 2012. Published by Elsevier B.V.
PMID: 22483185 [PubMed - indexed for MEDLINE]
The effect of herb-partition moxibustion on Toll-like receptor 4 in rabbit aorta during atherosclerosis.Yue ZH, He XQ, Chang XR, Yuan JL, Yu BS, Liu M, Fu L, Zhang L, Shang LC.
SourceCollege of Acu-Moxibustion and Tuina, Hunan University of Chinese Medicine, Changsha, Hunan, China.
AbstractOBJECTIVE:To explore the mechanism of Toll-like receptor (TLR4) inhibition in the delay of formation of atherosclerosis by herb-partitionmoxibustion.
METHOD:Seventy-five rabbits were randomly assigned to one of five groups: blank, atherosclerosis (AS) model, direct moxibustion, herb-partitionmoxibustion, and drug treatment. With the exception of the blank group, all rabbits were given a high-fat diet in addition to immunologic injury to create the AS model. The experiments were carried out for 16 weeks, at which time the aorta was removed from each rabbit. Immunohistochemical methods were used to detect the gray level of the aortic TLR4 to observe the immunologic competence of its antigens. Fluorescent quantitative polymerase chain reaction was used to detect the expression of TLR4 messenger RNA (mRNA) in the aorta.
RESULTS:The gray-scale value of TLR4 and the TLR4 mRNA expression significantly decreased (p<0.05) in the direct moxibustion, herb-partitionmoxibustion, and drug treatment groups. Furthermore, the effects of the herb-partition moxibustion and drug treatment were superior to those of the direct moxibustion.
CONCLUSION:Herb-partition moxibustion inhibits aortic TLR4 activity and mRNA expression, showing that herb-partition moxibustion delays the formation of atherosclerosis through the inhibition of TLR4 expression.
Copyright © 2012. Published by Elsevier B.V.
PMID: 22483185 [PubMed - indexed for MEDLINE]
Local thermal therapy effects on menopausal symptoms and bone mineral density.
J Altern Complement Med. 2011 Dec;17(12):1133-40. Epub 2011 Nov 21.
Local thermal therapy effects on menopausal symptoms and bone mineral density.Chien LW, Liu SJ, Chang Y, Liu CF.
SourceDepartment of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan.
Abstract OBJECTIVES:The aim of this study was to evaluate the effects of local thermal therapy with far-infrared rays (FIR) on menopausal symptoms and bone mineral density (BMD) in postmenopausal women.
SUBJECTS AND METHODS:A prospective randomized, controlled trial was conducted in female volunteers from communities in Northern Taiwan. The intervention group (n=22) received local thermal therapy with the help of FIR from an FIR emitter, for approximately 20 minutes per day, twice a week, for 20 sessions. They received the therapy on their backs while lying in a supine position. The control group (n=21) received no treatment. The primary outcome was the change in the Perceived Perimenopausal Disturbances Scale, designed for the measurement of menopause-related symptoms (MRS) before and after completion of treatment in a 10-week period. Secondary outcome parameters included serum levels of estradiol (E2) with osteocalcin (OC), and calcaneal BMD by quantitative ultrasound.
RESULTS:After 10 weeks of intervention, MRS determined by the scale decreased in mean total scores and mean scores for vasomotor, musculoskeletal, urologic, reproductive, and psychologic domains (p<0.05), except for reproductive (sexuality-related) symptoms. In the control group, mean total scores and scores of each domain had no significant difference between baseline and follow-up examination after 10 weeks. There was no significant difference between the quantitative ultrasound parameters in the calcaneus, serum E2, and OC levels either at the baseline or in the changes from the baseline between the intervention and control groups of women (p>0.05).
CONCLUSIONS:Local thermal therapy with FIR results in a significant reduction of MRS in postmenopausal women. Serum E2, OC levels, and calcaneal BMD showed no significant changes between the two groups. These results suggest that FIR local thermal therapy may be a potential alternative for the management of postmenopausal symptoms.
PMID: 22104026 [PubMed - indexed for MEDLINE]
Local thermal therapy effects on menopausal symptoms and bone mineral density.Chien LW, Liu SJ, Chang Y, Liu CF.
SourceDepartment of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan.
Abstract OBJECTIVES:The aim of this study was to evaluate the effects of local thermal therapy with far-infrared rays (FIR) on menopausal symptoms and bone mineral density (BMD) in postmenopausal women.
SUBJECTS AND METHODS:A prospective randomized, controlled trial was conducted in female volunteers from communities in Northern Taiwan. The intervention group (n=22) received local thermal therapy with the help of FIR from an FIR emitter, for approximately 20 minutes per day, twice a week, for 20 sessions. They received the therapy on their backs while lying in a supine position. The control group (n=21) received no treatment. The primary outcome was the change in the Perceived Perimenopausal Disturbances Scale, designed for the measurement of menopause-related symptoms (MRS) before and after completion of treatment in a 10-week period. Secondary outcome parameters included serum levels of estradiol (E2) with osteocalcin (OC), and calcaneal BMD by quantitative ultrasound.
RESULTS:After 10 weeks of intervention, MRS determined by the scale decreased in mean total scores and mean scores for vasomotor, musculoskeletal, urologic, reproductive, and psychologic domains (p<0.05), except for reproductive (sexuality-related) symptoms. In the control group, mean total scores and scores of each domain had no significant difference between baseline and follow-up examination after 10 weeks. There was no significant difference between the quantitative ultrasound parameters in the calcaneus, serum E2, and OC levels either at the baseline or in the changes from the baseline between the intervention and control groups of women (p>0.05).
CONCLUSIONS:Local thermal therapy with FIR results in a significant reduction of MRS in postmenopausal women. Serum E2, OC levels, and calcaneal BMD showed no significant changes between the two groups. These results suggest that FIR local thermal therapy may be a potential alternative for the management of postmenopausal symptoms.
PMID: 22104026 [PubMed - indexed for MEDLINE]
Moxibustion at mingmen reduces inflammation and decreases IL-6 in a collagen-induced arthritis mouse model.
J Acupunct Meridian Stud. 2012 Feb;5(1):29-33. Epub 2011 Dec 13.
Moxibustion at mingmen reduces inflammation and decreases IL-6 in a collagen-induced arthritis mouse model.Kogure M, Mimura N, Ikemoto H, Ishikawa S, Nakanishi-Ueda T, Sunagawa M, Hisamitsu T.
SourceDepartment of Physiology, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. [email protected]
AbstractThe purpose of this study was to compare the effectiveness of moxibustion (MOX) treatment at the GV4 and CV12 acupoints, and to determine the correlations between MOX treatment and interleukin (IL)-6 and corticosterone levels in a collagen-induced arthritis (CIA) mouse model. CIA mice were immunized twice intradermally over a 3-week interval with bovine type II collagen. After the second immunization (day 21), MOX was applied to the mouse equivalent of the GV4 and CV12 acupoints with a 1mg moxa cone five times/day. Clinical symptoms of CIA were observed three times/week until day 35. The concentrations of IL-6 and corticosterone in the blood samples were measured by immunoassay kits. At day 35, the incidence of CIA was significantly decreased in mice treated with MOX at the GV4 acupoint (78%, n=23, p<0.05), compared to untreated CIA mice (100%) and mice treated with MOX at the CV12 acupoint (100%). IL-6 and corticosterone levels were significantly increased by immunization. IL-6 levels significantly decreased in mice treated with MOX at the GV4 acupoint. These results suggest that MOX treatment suppressed CIA at the GV4 acupoint, not at the CV12 acupoint, possibly through inhibition of IL-6 production.
Copyright © 2012. Published by Elsevier B.V.
PMID: 22309905 [PubMed - indexed for MEDLINE]
Moxibustion at mingmen reduces inflammation and decreases IL-6 in a collagen-induced arthritis mouse model.Kogure M, Mimura N, Ikemoto H, Ishikawa S, Nakanishi-Ueda T, Sunagawa M, Hisamitsu T.
SourceDepartment of Physiology, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan. [email protected]
AbstractThe purpose of this study was to compare the effectiveness of moxibustion (MOX) treatment at the GV4 and CV12 acupoints, and to determine the correlations between MOX treatment and interleukin (IL)-6 and corticosterone levels in a collagen-induced arthritis (CIA) mouse model. CIA mice were immunized twice intradermally over a 3-week interval with bovine type II collagen. After the second immunization (day 21), MOX was applied to the mouse equivalent of the GV4 and CV12 acupoints with a 1mg moxa cone five times/day. Clinical symptoms of CIA were observed three times/week until day 35. The concentrations of IL-6 and corticosterone in the blood samples were measured by immunoassay kits. At day 35, the incidence of CIA was significantly decreased in mice treated with MOX at the GV4 acupoint (78%, n=23, p<0.05), compared to untreated CIA mice (100%) and mice treated with MOX at the CV12 acupoint (100%). IL-6 and corticosterone levels were significantly increased by immunization. IL-6 levels significantly decreased in mice treated with MOX at the GV4 acupoint. These results suggest that MOX treatment suppressed CIA at the GV4 acupoint, not at the CV12 acupoint, possibly through inhibition of IL-6 production.
Copyright © 2012. Published by Elsevier B.V.
PMID: 22309905 [PubMed - indexed for MEDLINE]
[Knee osteoarthritis treated with moxibustion: a randomized controlled trial].[Article in Chinese]
Zhongguo Zhen Jiu. 2011 Dec;31(12):1057-61.
[Knee osteoarthritis treated with moxibustion: a randomized controlled trial].[Article in Chinese]
Ren XM, Cao JJ, Shen XY, Wang LZ, Zhao L, Wu F, Zhang HM.
SourceAcupuncture-Moxibustion Department, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
AbstractOBJECTIVE:To observe the efficacy of moxibustion on the improvement in pain, stiffness and motor disturbance for the patients with knee osteoarthritis (OA) and evaluate the effectiveness and safety of moxibustion therapy.
METHODS:Fifty-nine cases of knee OA were randomly divided into a moxibustion group (31 cases) and a placebo moxibustion group (28 cases), in which moxa cone and placebo moxa sticker were applied to Neixiyan (EX-LE 4), Dubi (ST 35) and Ashi points separately, 3 cones on each point in each treatment. The treatment was given once every two days, 3 times per week, continuously for 6 weeks. The follow-up visit was performed in 6 weeks after the end of treatment. The Western Ontario and Mcmaster Universities Osteoarthritis Index (WOMAC) and the time of 46-meter walking at the fastest speed were adopted to evaluate the recovery of joint function. UT-325 digital thermal detector was used to record the temperature change at the most apparent pain points of knee joint before and after moxibustion treatment.
RESULTS:In moxibustion group, the scores in WOMAC were reduced apparently in 3 and 6 weeks treatment and during follow-up visit, separately (P < 0.05, P < 0.01, P < 0.001). In placebo moxibustion group, during follow-up visit, the score of stiffness was lower as compared with that before treatment (P < 0.05). In 6 weeks of treatment and during follow-up visit, the scores of pain, stiffness and motor disturbance in moxibustion group were reduced much more remarkably as compared with placebo moxibustion group (P < 0.01, P < 0.05). In moxibustion group, after treatment for 6 weeks,the time of 46-meter walking at the fastest speed was shorter apparently as compared with that before treatment (P < 0.01), but there was no apparent improvement after treatment in placebo moxibustion group (P > 0.05). The difference was not significant statistically in group comparison (P > 0.05). After moxibustion, the temperature at treatment point was (49.81 +/- 3.10) degrees C in moxibustion group and was (40.98 +/- 1.67) degrees C in placebo moxibustion group. The local skin temperature increased apparently as compared with that before treatment in either group (P < 0.001, P < 0.01), but the temperature increasing in moxibustion group was much more remarkable (P < 0.001).
CONCLUSION:Moxibustion can obviously improve in the clinical symptoms for the patients with knee osteoarthritis, such as pain, stiffness and motor disturbance. It is a safe and effective therapy.
PMID: 22256633 [PubMed - indexed for MEDLINE]
[Knee osteoarthritis treated with moxibustion: a randomized controlled trial].[Article in Chinese]
Ren XM, Cao JJ, Shen XY, Wang LZ, Zhao L, Wu F, Zhang HM.
SourceAcupuncture-Moxibustion Department, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China.
AbstractOBJECTIVE:To observe the efficacy of moxibustion on the improvement in pain, stiffness and motor disturbance for the patients with knee osteoarthritis (OA) and evaluate the effectiveness and safety of moxibustion therapy.
METHODS:Fifty-nine cases of knee OA were randomly divided into a moxibustion group (31 cases) and a placebo moxibustion group (28 cases), in which moxa cone and placebo moxa sticker were applied to Neixiyan (EX-LE 4), Dubi (ST 35) and Ashi points separately, 3 cones on each point in each treatment. The treatment was given once every two days, 3 times per week, continuously for 6 weeks. The follow-up visit was performed in 6 weeks after the end of treatment. The Western Ontario and Mcmaster Universities Osteoarthritis Index (WOMAC) and the time of 46-meter walking at the fastest speed were adopted to evaluate the recovery of joint function. UT-325 digital thermal detector was used to record the temperature change at the most apparent pain points of knee joint before and after moxibustion treatment.
RESULTS:In moxibustion group, the scores in WOMAC were reduced apparently in 3 and 6 weeks treatment and during follow-up visit, separately (P < 0.05, P < 0.01, P < 0.001). In placebo moxibustion group, during follow-up visit, the score of stiffness was lower as compared with that before treatment (P < 0.05). In 6 weeks of treatment and during follow-up visit, the scores of pain, stiffness and motor disturbance in moxibustion group were reduced much more remarkably as compared with placebo moxibustion group (P < 0.01, P < 0.05). In moxibustion group, after treatment for 6 weeks,the time of 46-meter walking at the fastest speed was shorter apparently as compared with that before treatment (P < 0.01), but there was no apparent improvement after treatment in placebo moxibustion group (P > 0.05). The difference was not significant statistically in group comparison (P > 0.05). After moxibustion, the temperature at treatment point was (49.81 +/- 3.10) degrees C in moxibustion group and was (40.98 +/- 1.67) degrees C in placebo moxibustion group. The local skin temperature increased apparently as compared with that before treatment in either group (P < 0.001, P < 0.01), but the temperature increasing in moxibustion group was much more remarkable (P < 0.001).
CONCLUSION:Moxibustion can obviously improve in the clinical symptoms for the patients with knee osteoarthritis, such as pain, stiffness and motor disturbance. It is a safe and effective therapy.
PMID: 22256633 [PubMed - indexed for MEDLINE]
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